Thursday, July 24, 2014

Anesthetics and Glucocorticoids for ALS

Note: I just received a note from Sharon Halton, a research coordinator at the Houston Methodist Neurological Institute saying "Our office has been conducting a study of dexamethasone for more than a year and we look forward to evaluating the results when the last of our subjects have completed their treatment." Let us hope it is a success. Regardless of the outcome, I maintain that the efficacy of dexamethasone is enhanced by anesthetics and vice versa. This synergistic interaction is why future treatments/experiments should consider using both concurrently. (7/25/14)

In 2007, my wife, who died of ALS last year, experienced a full recovery of her left foot paralysis immediately after spine surgery. Although she did not know it at the time, the paralysis was caused by ALS. Unfortunately, the symptoms returned within a month and it was downhill thereafter. After requesting her medical records, I learned that during the operation, she was anesthetized with inhalational anesthetics and she was given 2 grams of the antibiotic drug Cefazolin (Ancef) and 10 mg of Decadron (Dexamethasone), a very powerful glucocorticoid anti-inflammatory drug.

Excerpt
Somewhere around 2010, I became convinced that it was the anesthetics (propofol, sevoflurane, etc.) that had caused my wife's remission. The reason is that she also experienced a strong remission of her ALS symptoms immediately after other surgical procedures during which she was anesthetized. But the main reason that I dismissed dexamethasone is that I was assured by ALS experts that anti-inflammatory drugs have been tried many times before and were shown to be completely ineffective against ALS. This turned out to be a lie, the big lie about ALS that Big Pharma has preached for many years. I now understand that it was a combination of the anesthetics and the glucocorticoid anti-inflammatory drug, routinely given during such procedures, that had caused her improvements. Both have anti-inflammatory properties. I did some research and found out that they work synergistically by enhancing and complementing each other's therapeutic properties.

I hold Big Pharma, the Department of Health and Human Services and the ALS therapy development industry responsible for my wife's death and that of countless others who perished from this horrible disease.

ALS Is an Autoimmune Disease

Even though many in the ALS money making industry maintain otherwise, there is no question that ALS is an autoimmune disease. This is why my wife and other ALS sufferers have experienced strong improvements after injection with anti-inflammatory drugs. This is not the first time that glucocorticoid drugs have been implicated in spectacular ALS remissions. In 2011, famous ALS patient Ted Harada experienced an amazing recovery after being anesthetized for up to five hours during stem cell treatment and given several anti-inflammatory glucocorticoids to prevent rejection. In June 2013, Ernie Schmid published an ALS remission story in which he explained how he kept his ALS under control with powerful glucocorticoids. There is also the story of US Authors Guild's director Paul Aiken whose ALS went into remission after injections with the glucocorticoid drug Kenalog. Other ALS sufferers have reported strong improvements in their speech and ability to swallow after a visit to the dentist. It turns out that most dentists inject their patients with a mixture of dexamethasone (to prevent swelling) and a local anesthetic during tooth extractions or root canals.

I would hate to see so many ALS sufferers needlessly die from this awful disease while a cheap and effective treatment might be available off the shelf. Unfortunately, we have a broken and heartless health system that refuses to listen to the opinions of their terminal patients and forbids them to experiment with various drugs, even under doctor's supervision. We sorely need a 'right to try' law for terminal patients.

See Also:

Alternative Anti-Inflammatory Remedies for ALS
The Evil Lie about ALS
Treat ALS with Anti-Inflammatory Drugs

PS. If you have ALS or you care for someone who does, please do what you can to get your hands on some dexamethasone and conduct your own experiments at home. It's a relatively benign drug. Just make sure you don't have any infection before you begin to experiment with it.

Discussions